Spreading Clean Beauty

Senolysis: how AI is paving the way for groundbreaking well-aging

At Provital, our constant quest for innovation in cosmetic science has lately turned our efforts towards senolysis. As skin aging continues to be a crucial segment within the cosmetic industry, looking at senescent cells within aging processes represents an essential field where a multitude of exciting discoveries lie ahead. 

Since 1992 and building up to become Bronze sponsors, our annual participation at IFSCC Congress is an opportunity to take a look at the pace of our developments as part of our commitment towards innovation in the cosmetic industry. 

Known as the ‘Nobel Prize for cosmetic science’, this congress can provide a clear picture for what innovation in cosmetic science looks like today and in the next few years.

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Among the key innovations shared in the case of the 33rd IFSCC Congress in 2023, our work within the field of senolysis is key. Let’s take a look at our research in this area, which was already a protagonist of the 2020 edition, and comes back in 2023 by incorporating Artificial Intelligence.

The ground-breaking cosmetic innovation around senolysis

Skin ageing cosmetics have longed to define what ageing means. In this context, the concept of senescent cells opened the door for breakthrough innovation. 

Simply put, senescent cells are those cells that have entered a state of irreversible cell cycle arrest, meaning they are no longer actively dividing and proliferating. Senescence is, in fact, a natural biological process that can occur in response to various factors, including DNA damage, oxidative stress, and cellular dysfunction. While senescence serves as a mechanism to prevent damaged cells from becoming cancerous, the accumulation of senescent cells in tissues over time can lead to chronic inflammation and tissue dysfunction, contributing to the ageing process and age-related diseases.

In fact, the accumulation of senescent cells over time is one of the hallmarks of ageing, being correlated with visible signs of advanced skin age, such as wrinkles and lack of elasticity.

Through senolysis, it’s possible to selectively eliminate senescent cells from the body, generating an attractive strategy to develop cosmetic actives with anti-ageing properties. As such, a senolytic mechanism aims to target and remove senescent cells to promote healthier ageing and potentially slow the progression of age-related diseases. 

At Provital, we have been investigating the potential of senolysis for developing effective well-aging cosmetic treatments. This led us to present a very promising candidate in the 2020’s IFSCC Congress: Althaea rosea stem cells that induce the selective elimination of senescent cells. In fact, this development was recognized as a TOP10 scientific poster in IFSCC 2020 for its innovation in the in vitro quantification of senolysis for the treatment of aging skinr.

How AI pushes forward our past research on senolysis

In 2023, we take this research a step forward. In a new paper presented in the upcoming 33rd IFSCC Congress, we share how the incorporation of AI has enabled us to evaluate the efficacy of this – recently launched – senolytic active, in vivo. 

As such, we have been able to study the well-aging effect of our Altheostem™ using a new tool based on AI that is able to analyze and estimate the apparent age of the candidates’ faces.

Of course, we first analized at a number of instrumental parameters, by looking at facial skin measurements of radiance (Colorimeter), elasticity (Cutometer), profilometry (Primos 3D), thickness (Ultrasound); as well as an estimation of age appearance through wrinkle depth quantification. However, we completed the study with a very innovative image analysis tool based on machine learning and neural networks that provided a super accurate estimation of age like the industry has never seen before.

The results of this last AI-based experiment show how, in vivo, Altheostem™ provides a total rejuvenating effect of 3.26 years, besides significantly improving the radiance, elasticity, and the thickness of the skin, promoting a decrease in volume and depth of wrinkles and a reduction in the estimated age as revealed both by analysis of periocular wrinkle depth measure (“x-year less effect”) and by estimation of the apparent age using Artificial Intelligence tools. 

As such, the combination of cutting-edge cosmetic science and technology at Provital has allowed us to take yet another step in providing efficient and innovative well-aging treatments. 

Taking the opportunity to discuss our research at the 33rd IFSCC Congress thus represents a chance to share our commitment for the advancement of the cosmetic industry in the path for increased ingredient efficacy supported by technology, science and sustainable development.

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