Skin Regeneration Ingredients: Advanced Technology for Optimizing Skin Cell Health

Skin regeneration is the skin’s natural way of repairing and renewing itself, maintaining its health and appearance. This vital process ensures the skin’s  protective barrier function, protecting us from environmental factors and pathogens, and keeping our skin looking its best.

Skin Regeneration Process

What is skin regeneration and why is it important?

Skin regeneration involves a complex sequence of cellular activities that include cell growth, movement, specialization, and the rebuilding of the skin’s support structure. The epidermal turnover, specifically, is a natural and continuous process where skin sheds dead skin cells from its surface and replaces them with new, younger cells. This process primarily occurs in the epidermis, the skin’s outermost layer.  
 

Epidermal turnover: Understanding the skin regeneration cycle

New skin cells are constantly being created in the deepest layer of the epidermis, called the stratum germinativu. These new cells then begin a journey upwards through the different layers of the epidermis. As they mature and move towards the surface, they undergo changes, eventually becoming the tough, dry, and flaky cells that make up the outer layer, the stratum corneum.   

Once these stem cells reach the stratum corneum, they are essentially dead skin cells. Ideally, new cells continuously arrive at the surface, pushing the older, dead cells off. This shedding of dead skin cells is called desquamation. These old skin cells are what eventually become dust.   

Maintaining a healthy epidermal turnover is important for several reasons, including keeping the skin’s surface smooth, promoting an even skin tone, and helping wounds and blemishes heal faster.

 
How long does it take for skin to regenerate?

The complete cycle of skin regeneration, specifically the epidermal turnover, typically takes approximately 28 days in young adults, but this duration can significantly increase with age, slowing down to 45-50 days in older individuals (based on external knowledge). Furthermore, the efficiency of epidermal turnover is compromised in conditions such as acne-prone skin and aged skin.

Notably, Pureblome™ has demonstrated the capacity to significantly decrease the Stratum Corneum Turnover Time (SCTT) in vivo. A decrease in SCTT, as observed with Pureblome™, is indicative of its overall regenerating capacity and highlights its efficacy in promoting skin renewal. This accelerated turnover contributes to the visible improvements in skin texture and appearance associated with Pureblome™ treatment.

The Stratum Corneum Turnover Time is the time it takes for a skin cell to travel from the basal layer (the deepest layer of the epidermis) up to the surface of the skin (the stratum corneum) and eventually be shed. Let’s think of it as a conveyor belt for skin cells. New cells are constantly being produced at the bottom, pushing the older, keratinized cells upwards until they reach the surface and slough off.

Pureblome ™’s SCTT instrumental measurement used patch tests containing DHA, applied on the surface of volunteers’ forearms to give the skin a brown tint. Skin color on each area is instrumentally and visually evaluated before DHA application, 24h after DHA patch removal, and in the subsequently fixed checkpoints, with a spectrophotometer/colorimeter. Then, a calculation of ITAº values (Individual Typology Angles) was performed to analyze the pigmentation intensity (the higher the ITA°, the lighter the pigmentation). 
 

Factors that influence skin cell renewal

The impact of aging and lifestyle on skin regeneration

Aging naturally slows down skin regeneration due to reduced fibroblast activity, decreased collagen production, and other factors. Lifestyle choices also play a significant role. Stress hormones, lack of sleep, poor diet, and environmental aggressors like UV radiation can all hinder skin regeneration. 
 

Advanced technology for optimizing skin cell health

Advanced delivery technologies and biotechnological ingredients are used in skincare to improve the effectiveness of skin-regenerating ingredients. These technologies enhance the penetration, stability, and bioavailability of active compounds.

Provital’s Triplobiome™ Technology is a cutting-edge biotech platform for sourcing and delivering skin-renewing actives. This technology utilizes plant endophytes, microorganisms that live within plant tissues, as a sustainable source of new natural active ingredients. By harnessing the symbiotic relationship between plants and their endophytes, Triplobiome™ provides unique benefits for skin health and regeneration. 
 

Pureblome™: The breakthrough in skin regeneration

What makes Pureblome™ unique?

Pureblome™ is a novel post-biotic ingredient powered by Provital’s Triplobiome™ Technology. It is designed to mirror the balance of a natural ecosystem for comprehensive skin equilibrium.

Pureblome™ is an agro-psychological solution that combines the psychological benefits of nature with the physical renewal of sustainable practices. It harnesses the power of the symbiotic relationship between agroecological hyssop and its endophytic bacteria. Pureblome™ offers a triple efficacy approach, addressing the needs of mature women with anti-acne, well-aging, and anti-inflammaging benefits. 

How does Pureblome accelerate skin renewal?

Pureblome™ enhances fibroblast revitalization, increasing cell migration, which is important for wound healing and dermal regeneration. It also boosts the synthesis of Collagen I and Elastin, supporting skin restructuring and well-aging. Pureblome™ reduces the formation of Advanced Glycation End products (AGEs), helping to maintain skin elasticity.

In vivo studies have demonstrated that Pureblome™ decreases Stratum Corneum Turnover Time by almost 2 days vs placebo, hence proving its skin renewing power. It also improves skin elasticity and smoothness. 
 

 
The science behind Pureblome

Triplobiome™ Technology: The power of nature in skin renewal

Triplobiome™ Technology is Provital’s innovative biotech platform that leverages interkingdom symbiosis, offering a transformative approach to beauty, using the adaptive power of nature. This technology supports eco-responsible beauty by developing traceable and sustainable ingredients. For Pureblome™, the endophytic bacteria Bacillus velezensis was isolated from the agroecological hyssop. 

Key active compounds in Pureblome

Pureblome™ contains a synergistic array of bioactive compounds derived from the bio-fermentation of Bacillus velezensis. 

These compounds include:

• Peptides (<8KDa): These peptides contribute to Pureblome™‘s well-aging and skin restructuring properties (Suchi et al., 2017). 
• Lipopeptides (e.g., Surfactin): These have antimicrobial activity, can disrupt bacteria like Cutibacterium acnes, and reduce inflammation. Surfactin also stimulates collagen production, inhibits enzymes that break down the skin matrix, and reduces wrinkles. It also has antioxidant activity. Other lipopeptides found in the bacillus ferment, such as Iturin and Fengycin, also contribute to antimicrobial and skin-regenerative effects. 
• Other plant metabolites: These contribute to Pureblome™’s anti-inflammatory, antioxidant, and skin-balancing activities. Broussonetinine A, a notable metabolite, helps prevent the formation of glycation end products (AGEs) (Mandour et al., 2020). 

 
The future of skin regeneration

The future of skin regeneration in cosmetics relies on sustainable and biotechnologically advanced approaches that utilize the power of nature. Further research into plant-microbiome interactions will likely lead to the discovery of new bioactive compounds. Holistic skincare solutions that consider the skin microbiome, environmental factors, and the body’s internal state will become increasingly important. Ingredients like Pureblome™, which use interkingdom symbiosis and sustainable sourcing, point towards the future of effective and responsible skin regeneration. 

 
Best practices for maintaining healthy skin renewal

Supporting healthy skin renewal requires a comprehensive approach that addresses both internal and external factors. 

This includes:

• Adopting a holistic lifestyle: A balanced diet, stress management, and adequate sleep are essential. 
• Protecting the skin from environmental damage: Consistent sunscreen use and minimizing exposure to pollutants are crucial. 
• Establishing a consistent and gentle skincare routine: Gentle cleansing and moisturizing are important for cell turnover. 
• Incorporating advanced and scientifically backed ingredients: Ingredients like Pureblome™, powered by Triplobiome™ Technology, can accelerate skin renewal and address multiple skin concerns. 
• Choose products that are traceable and sustainably produced. 

For further information or insights on this topic, please do not hesitate to contact our team of experts, who are available to provide guidance and support in selecting the most suitable solutions for your requirements.